Anti-cdc25C (Ab-216) Antibody

cdc25C is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. <br><br>Toyoshima-Morimoto F. et al. (2002) EMBO Rep. 3(4): 341-348. <br>Ferguson AM. et al. (2005) Mol Cell Biol. 25(7): 2853-2860. <br>Donzelli M. et al. (2003) EMBO Rep. 4(7): 671-677. <br>Chen F. et al. (2002) Proc Natl Acad Sci U S A. 99(4): 1990-1995.

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.