Anti-PTH-rP PTHLH Antibody

Boster Bio Anti-PTH-rP PTHLH Antibody catalog # A01321. Tested in WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Parathyroid hormone-related protein; PTH-rP; PTHrP; Parathyroid hormone-like protein; PLP; PTHrP[1-36]; PTHrP[38-94]; Osteostatin; PTHrP[107-139]; PTHLH; PTHRP

Gene Name

PTHLH

UniProt

P12272

Host

Rabbit

Reactivity

Human

Immunogen

The antiserum was produced against synthesized peptide derived from the Internal region of human PTHLH. AA range:101-150

Tissue Specificity

Ubiquitous. Also expressed in the mammary gland.

Applications

Purification

Immunogen affinity purified

Form

Liquid

Function

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity) . Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1- dependent manner through activation of Rac1. .