Anti-NFkB-p100 (Ab-866) NFKB2 Antibody

NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. <br> <br> Qu Z, et al. (2004) J Biol Chem. 279(43): 44563-44572. <br> Xiao G, et al. (2001) Mol Cell. 7(2): 401-409. <br> Baeuerle P A, et al. (1994) Annu Rev Immunol. 12:141-179. <br> Baeuerle P A, et al. (1996) Cell 87:13-20. <br> Haskill S, et al. (1991) Cell 65:1281-1289. <br>

Apoptosis, Apoptotic Markers, Cancer, Cell Biology, Cell Death, Epigenetics and Nuclear Signaling, Intracellular, NFKB Pathway, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Transcription

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.