Anti-IkB-a (Ab-32/36) NFKBIA Antibody

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription. <br><br>Mattioli I, et al. (2004)J Immunol; 172(10): 6336-44. <br>Courtois G, et al. (2003)J Clin Invest; 112(7): 1108-15. <br>Nair A, et al. (2003) Oncogene; 22(1): 50-8. <br>Fan C, et al. (2002)J Cell Sci; 115(Pt 24): 4843-53. <br>Schubert SY, et al. (2002)FASEB J; 16(14): 1931-3.

Cancer, Epigenetics and Nuclear Signaling, Immunology, Innate Immunity, NFKB Pathway, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, TLR Signaling

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.