Anti-KCNH1 Antibody

Potassium voltage-gated channel subfamily H member 1; Ether-a-go-go potassium channel 1; EAG channel 1; h-eag; hEAG1; Voltage-gated potassium channel subunit Kv10.1; KCNH1; EAG, EAG1

Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.

Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247) . Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity) . Mediates IK (NI) current in myoblasts (PubMed:9738473) . Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642) . .

Cell membrane ; Multi- pass membrane protein . Nucleus inner membrane ; Multi-pass membrane protein . Early endosome membrane . Perinuclear KCNH1 is located to NPC-free islands.