Anti-GSK3b (Ab-9) Antibody

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. <br> <br> Fan G, et al. (2003) J Biol Chem. 278(52): 52432-52436. <br> Barry FA, et al. (2003) FEBS Lett. 553(1-2): 173-178. <br> Welsh, et al. (1996) Trends Cell Biol. 6: 274-279. <br> Srivastava A K, et al. (1998) Mol Cell Biochem. 182: 135-141. <br> Cross D. A, et al. (1995) Nature. 378: 785-789.

Carbohydrate Metabolism, Cell Biology, Cell Cycle, Cell Differentiation, Developmental Biology, Energy Metabolism, Metabolic Signaling Pathways, Metabolism, Nervous System Development, Neurogenesis, Neurology Process, Neuroscience, Organogenesis, Pathways and Processes, Signal Transduction

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.