Anti-syk (Ab-323) Antibody

Positive effector of BCR-stimulated responses. Couples the B-cell antigen receptor (BCR) to the mobilization of calcium ion either through a phosphoinositide 3-kinase-dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C-gamma-dependent pathway, when phosphorylated on Tyr-348 and Tyr-352. Thus the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion <br><br>Zhang, J. et al. (2000) J. Biol. Chem. 275, 35442-35447. <br>Turner, M. et al. (2000) Immunol. Today 21, 148-154. <br>Decker, M. et al. (1998) J. Biol. Chem. 273, 8867-8874. <br>Law, C.L. et al. (1996) Mol. Cell. Biol. 16, 1305-1315.

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.