Anti-ERCC1 Antibody

Isoform 1:Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.<br><br>Kan-Tai Hsia, Development, Jan 2003; 130: 369.<br>Jim Selfridge, Nucleic Acids Res., Nov 2001; 29: 4541 - 4550.<br>Cha-Kyung Youn, Cancer Res., Jul 2004; 64: 4849 - 4857.<br>Teresa A. Motycka, J. Biol. Chem., Apr 2004; 279: 13634 - 13639.

Isoform 1: Non-catalytic component of a structure- specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL) . Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.