Anti-ERCC1 Antibody
Boster Bio Anti-ERCC1 Antibody (Catalog # A00388-1) . Tested in WB, IHC applications. This antibody reacts with Human, Mouse.
Product Specifications
Background
Isoform 1:Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.<br><br>Kan-Tai Hsia, Development, Jan 2003; 130: 369.<br>Jim Selfridge, Nucleic Acids Res., Nov 2001; 29: 4541 - 4550.<br>Cha-Kyung Youn, Cancer Res., Jul 2004; 64: 4849 - 4857.<br>Teresa A. Motycka, J. Biol. Chem., Apr 2004; 279: 13634 - 13639.
Synonyms
DNA excision repair protein ERCC-1; ERCC1
Gene Name
ERCC1
UniProt
P07992
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from human ERCC1.
Clonality
Polyclonal
Applications
WB, IHC
Field of Research
Cancer, DNA/RNA, DNA Damage & Repair, Epigenetics and Nuclear Signaling, Tumor Biomarkers
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Form
Liquid
Function
Isoform 1: Non-catalytic component of a structure- specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL) . Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.
Molecular Weight
32562 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
DNA excision repair protein ERCC-1
Subcellular Location
Isoform 1: Nucleus.
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