Anti-a-Synuclein (Ab-133) SNCA Antibody

May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. <br><br>Kozikowski AP, et al. (2006)ChemMedChem. 1(2):256-66. <br>Jakowec MW, et al.(2001)Dev Neurosci.23(2):91-9. <br>El-Agnaf OM, et al.(1998)FEBS Lett. 440(1-2):67-70.

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.