Anti-a-Synuclein (Ab-133) SNCA Antibody
Boster Bio Anti-a-Synuclein (Ab-133) SNCA Antibody (Catalog # A00215-2) . Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
<br><br>Kozikowski AP, et al. (2006)ChemMedChem. 1(2):256-66.
<br>Jakowec MW, et al.(2001)Dev Neurosci.23(2):91-9.
<br>El-Agnaf OM, et al.(1998)FEBS Lett. 440(1-2):67-70.
Gene Name
SNCA
UniProt
P37840
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Peptide sequence around aa. 131~135 (E-G-Y-Q-D) derived from Human a-Synuclein.
Clonality
Polyclonal
Applications
WB, IF
Field of Research
Alzheimer's Disease, Neurodegenerative Disease, Neurology Process, Neuroscience
Purification
Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/ml
Form
Liquid
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A00215-2
Product MSDS
https://www.bosterbio.com/msds?sku=A00215-2
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