Ursolic acid acetate

Ursolic acid acetate (Acetylursolic acid) is a triterpenoid compound and an inhibitor of Plasmodium falciparum heat shock protein 90 (PfHsp90) with a KD of 8.16 μM. Ursolic acid acetate is cytotoxic to KB cells, with an IC50 value of 8.4 μM. Ursolic acid acetate can be used in tumor and antimalarial research[1][2][3].

Product Specifications

CAS Number

[7372-30-7]

Product Name Alternative

Acetylursolic acid; 3-Acetylursolic acid

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

HSP; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/ursolic-acid-acetate.html

Purity

98.0

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[H][C@]12C3=CC[C@]4([C@@](CC[C@]5(C(C)([C@H](CC[C@@]54C)OC(C)=O)C)[H])([C@@]3(CC[C@]1(CC[C@H]([C@@H]2C)C)C(O)=O)C)C)[H]

Molecular Formula

C32H50O4

Molecular Weight

498.74

Precautions

H315, H319, H335

References & Citations

[1]Chiang YM, et al. Cytotoxic triterpenes from the aerial roots of Ficus microcarpa. Phytochemistry. 2005 Feb;66 (4) :495-501.|[2]Nndwammbi AAT, et al. Ursolic acid acetate and iso-mukaadial acetate bind to Plasmodium falciparum Hsp90, abrogating its chaperone function in vitro. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jul;397 (7) :5179-5192.|[3]Gnoatto S C B, et al. Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4- (3-aminopropyl) piperazinyl] propyl}-3-O-acetylursolamide derivatives as antimalarial agents. Bioorganic & medicinal chemistry, 2008, 16 (2) : 771-782.