PROTAC TRIB2 degrader-1
Product Specifications
UNSPSC Description
PROTAC TRIB2 degrader-1 (Compound 5k) is an effective TRIB2 degrader that selectively induces TRIB2 degradation through the CRBN-dependent ubiquitin-proteasome pathway. PROTAC TRIB2 degrader-1 can inhibit cell proliferation and induce cell apoptosis, and can be used in cancer research. (Target protein ligand (Pink): HY-168275; linker (black): HY-168276; E3 Ligase Ligand-Linker Conjugates: HY-168277; E3 ligase (Blue): HY-W023573)[1].
Target Antigen
Apoptosis; PROTACs
Type
Reference compound
Related Pathways
Apoptosis;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-trib2-degrader-1.html
Smiles
O=C(C1=NNC2=C1C=C(C3=CC=CN=C3F)C=C2)NC4=CC5=C(C=C4)CCN(C(CCCCCCCCCNC6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)=O)C5
Molecular Weight
812.89
References & Citations
[1]Wen C, et al. Discovery of the First Selective and Potent PROTAC Degrader for the Pseudokinase TRIB2[J]. European Journal of Medicinal Chemistry, 2024: 117016.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168274/PROTAC-TRIB2-degrader-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168274/
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![ALK Mouse Monoclonal Antibody [Clone ID: LBI5C8]](https://cdn.genprice.uk/genprice/genprice2.png)
