PROTAC TRIB2 degrader-1

PROTAC TRIB2 degrader-1 (Compound 5k) is an effective TRIB2 degrader that selectively induces TRIB2 degradation through the CRBN-dependent ubiquitin-proteasome pathway. PROTAC TRIB2 degrader-1 can inhibit cell proliferation and induce cell apoptosis, and can be used in cancer research. (Target protein ligand (Pink) : HY-168275; linker (black) : HY-168276; E3 Ligase Ligand-Linker Conjugates: HY-168277; E3 ligase (Blue) : HY-W023573) [1].

Product Specifications

CAS Number

[3100306-42-8]

UNSPSC

12352005

Target

Apoptosis; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-trib2-degrader-1.html

Smiles

O=C(C1=NNC2=C1C=C(C3=CC=CN=C3F)C=C2)NC4=CC5=C(C=C4)CCN(C(CCCCCCCCCNC6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)=O)C5

Molecular Formula

C45H45FN8O6

Molecular Weight

812.89

References & Citations

[1]Wen C, et al. Discovery of the First Selective and Potent PROTAC Degrader for the Pseudokinase TRIB2[J]. European Journal of Medicinal Chemistry, 2024: 117016.