PROTAC TRIB2 degrader-1
PROTAC TRIB2 degrader-1 (Compound 5k) is an effective TRIB2 degrader that selectively induces TRIB2 degradation through the CRBN-dependent ubiquitin-proteasome pathway. PROTAC TRIB2 degrader-1 can inhibit cell proliferation and induce cell apoptosis, and can be used in cancer research. (Target protein ligand (Pink) : HY-168275; linker (black) : HY-168276; E3 Ligase Ligand-Linker Conjugates: HY-168277; E3 ligase (Blue) : HY-W023573) [1].
Product Specifications
CAS Number
[3100306-42-8]
UNSPSC
12352005
Target
Apoptosis; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-trib2-degrader-1.html
Smiles
O=C(C1=NNC2=C1C=C(C3=CC=CN=C3F)C=C2)NC4=CC5=C(C=C4)CCN(C(CCCCCCCCCNC6=CC7=C(C(N(C(CC8)C(NC8=O)=O)C7=O)=O)C=C6)=O)C5
Molecular Formula
C45H45FN8O6
Molecular Weight
812.89
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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