NVP-DPP728 (dihydrochloride)

NVP-DPP728 dihydrochloride is a potent, selective and orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 11 nM. NVP-DPP728 dihydrochloride can be used for the research of diabetes mellitus[1][2].

Product Specifications

CAS Number

[207556-62-5]

UNSPSC

12352005

Target

Dipeptidyl Peptidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/nvp-dpp728-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

N#CC1=CC=C(NCCNCC(N2[C@H](C#N)CCC2)=O)N=C1.[H]Cl.[H]Cl

Molecular Formula

C15H20Cl2N6O

Molecular Weight

371.26

References & Citations

[1]T E Hughes, et al. NVP-DPP728 (1-[[[2-[ (5-cyanopyridin-2-yl) amino]ethyl]amino]acetyl]-2-cyano- (S) - pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry. 1999 Sep 7;38 (36) :11597-603.|[2]B Balkan, et al. Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats. Diabetologia. 1999 Nov;42 (11) :1324-31.