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Endothelin-1 (1-31) (Human) (TFA)

Endothelin-1 (1-31) (Human) TFA is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) TFA is derived from the selective hydrolysis of big ET-1 by chymase[1].

Product Specifications

UNSPSC

12352209

Target

ERK

Type

Peptides

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/endothelin-1-1-31-human-tfa.html

Purity

99.79

Solubility

H2O : 50 mg/mL (adjust pH to 10 with NH4OH)

Smiles

O=C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N[C@@H](CC4=CN=CN4)C(N[C@H](C(N[C@H](C(N5[C@H](C(N[C@@H](CC6=CC=C(O)C=C6)C(O)=O)=O)CCC5)=O)C(C)C)=O)C(C)C)=O)=O)CCC(O)=O)=O)CCC3)=O)[C@@H](C)O)=O)CC(N)=O)=O)C(C)C)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CC(O)=O)=O)CC(C)C)=O)CC7=CN=CN7)[C@H]8NC([C@H](CC9=CC=CC=C9)NC([C@H](CC%10=CC=C(O)C=C%10)NC([C@H](C(C)C)NC([C@]%11(NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CO)NC([C@@]([H])(NC([C@H](CO)NC([C@@H](N)CSSC8)=O)=O)CSSC%11)=O)=O)=O)=O)=O)=O)=O)=O)[H])=O)=O)=O)=O.O=C(O)C(F)(F)F

Molecular Formula

C164H237F3N38O49S5

Molecular Weight

3742.18

References & Citations

[1]Matsumoto T, et al. Gender differences in vascular reactivity to endothelin-1 (1-31) in mesenteric arteries from diabetic mice. Peptides. 2008 Aug;29 (8) :1338-46.|[2]Yoshizumi M, et al. Effect of endothelin-1 (1-31) on human mesangial cell proliferation. Jpn J Pharmacol. 2000 Oct;84 (2) :146-55.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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