Parbendazole

Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.

Product Specifications

CAS Number

[14255-87-9]

Product Name Alternative

SKF 29044

UNSPSC

12352005

Hazard Statement

H302, H361

Target

Microtubule/Tubulin; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Cytoskeleton

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Parbendazole.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : 4 mg/mL (ultrasonic)

Smiles

O=C(OC)NC1=NC2=CC=C(CCCC)C=C2N1

Molecular Formula

C13H17N3O2

Molecular Weight

247.29

Precautions

H302, H361

References & Citations

[1]Lo YC, et al. Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential. Sci Rep. 2017 Sep 12;7 (1) :11261.|[2]Havercroft JC, et al. Binding of parbendazole to tubulin and its influence on microtubules in tissue-culture cells as revealed by immunofluorescence microscopy. J Cell Sci. 1981 Jun;49:195-204.|[3]Foster KE, et al. A mutant beta-tubulin confers resistance to the action of benzimidazole-carbamate microtubule inhibitors both in vivo and in vitro. Eur J Biochem. 1987 Mar 16;163 (3) :449-55.