Parbendazole
Parbendazole is a potent inhibitor of microtubule assembly, destabilizes tubulin, with an EC50 of 530 nM, and exhibits a broad-spectrum anthelmintic activity.
Product Specifications
CAS Number
14255-87-9
Product Name Alternative
SKF 29044
UNSPSC
12352005
Hazard Statement
H302, H361
Target
Microtubule/Tubulin; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Cytoskeleton
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Parbendazole.html
Concentration
10mM
Purity
99.92
Solubility
DMSO : 4 mg/mL (ultrasonic)
Smiles
O=C(OC)NC1=NC2=CC=C(CCCC)C=C2N1
Molecular Formula
C13H17N3O2
Molecular Weight
247.29
Precautions
H302, H361
References & Citations
[1]Lo YC, et al. Computational Cell Cycle Profiling of Cancer Cells for Prioritizing FDA-Approved Drugs with Repurposing Potential. Sci Rep. 2017 Sep 12;7 (1) :11261.|[2]Havercroft JC, et al. Binding of parbendazole to tubulin and its influence on microtubules in tissue-culture cells as revealed by immunofluorescence microscopy. J Cell Sci. 1981 Jun;49:195-204.|[3]Foster KE, et al. A mutant beta-tubulin confers resistance to the action of benzimidazole-carbamate microtubule inhibitors both in vivo and in vitro. Eur J Biochem. 1987 Mar 16;163 (3) :449-55.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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