(2S,6S) -Hydroxynorketamine (hydrochloride)

(2S,6S) -Hydroxynorketamine hydrochloride is a neurorelaxant with potential antidepressant and analgesic effects. (2S,6S) -Hydroxynorketamine hydrochloride can activate the mTOR pathway, increase the phosphorylation level of downstream targets, and antagonize α7-nicotinic acetylcholine receptor (nAChR) to exert neuroactive properties[1].

Product Specifications

CAS Number

[1430202-70-2]

Product Name Alternative

(2S,6S) -HNK (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MTOR; nAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_2S,6S_-HNK_hydrochloride.html

Purity

99.30

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : ≥ 50 mg/mL

Smiles

N[C@]1(C([C@H](CCC1)O)=O)C2=C(C=CC=C2)Cl.Cl

Molecular Formula

C12H15Cl2NO2

Molecular Weight

276.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Paul RK, et al. (R, S) -Ketamine metabolites (R, S) -norketamine and (2S,6S) -hydroxynorketamine increase the mammalian target of rapamycin function. Anesthesiology. 2014 Jul;121 (1) :149-59.