EBOV-IN-1

EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV) . EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM[1].

Product Specifications

CAS Number

[1335113-30-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Filovirus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ebov-in-1.html

Purity

98.55

Solubility

10 mM in DMSO

Smiles

COC(=O)C1=CC=C(COC2=CC=CC=C2CN2CCN(C(=O)CNC(=O)CC34CC5CC(CC(C5)C3)C4)CC2)C=C1

Molecular Formula

C34H43N3O5

Molecular Weight

573.72

Precautions

H302, H315, H319, H335

References & Citations

[1]Liu H, et al. Identification of Potent Ebola Virus Entry Inhibitors with Suitable Properties for in Vivo Studies. J Med Chem. 2018 Jul 26;61 (14) :6293-6307.