7-Methylguanine

7-Methylguanine is an orally active and competitive PARP-1 inhibitor with a Ki value of 61 μM. 7-Methylguanine is a metabolite of nucleic acids. 7-Methylguanine has anticancer activity against uterine sarcoma and colon adenocarcinoma. 7-Methylguanine is used as a probe for protein-DNA interactions[1][2][3][4][5][6].

Product Specifications

CAS Number

[578-76-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; PARP

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/7-Methylguanine.html

Purity

99.97

Solubility

1 M NaOH : ≥ 100 mg/mL|H2O : 4.72 mg/mL (ultrasonic; adjust pH to 11 with 1 M NaOH)

Smiles

O=C1NC(N)=NC2=C1N(C)C=N2

Molecular Formula

C6H7N5O

Molecular Weight

165.15

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee S, et al. Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J Am Chem Soc. 2008 Sep 3;130 (35) :11570-1.|[2]Kurgina TA, et al. Inhibitory Effects of 7-Methylguanine and Its Metabolite 8-Hydroxy-7-Methylguanine on Human Poly (ADP-Ribose) Polymerase 1. Biochemistry (Mosc) . 2022 Aug;87 (8) :823-831.|[3]Nilov D, et al. Molecular Mechanisms of PARP-1 Inhibitor 7-Methylguanine. Int J Mol Sci. 2020 Mar 20;21 (6) :2159. |[4]Kirsanov K, et al. Toxicological Properties of 7-Methylguanine, and Preliminary Data on its Anticancer Activity. Front Pharmacol. 2022 Jul 6;13:842316. |[5]Gaubatz JW, et al. Introduction, distribution, and removal of 7-methylguanine in different liver chromatin fractions of young and old mice. Mutat Res. 1997 Apr 14;375 (1) :25-35. |[6]Kirsanov K, et al. 7-Methylguanine Inhibits Colon Cancer Growth in Vivo. Acta Naturae. 2024 Apr-Jun;16 (2) :50-52.