Big Endothelin-1 (Rat, 1-39)

<strong>Big Endothelin-1 (Rat, 1-39)</strong> <strong>Catalog number:</strong> MDP0641 <strong>CAS Number: </strong>208253-85-4 <strong>Sequence: </strong>Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-Arg-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser (Disulfide bonds between Cys1-Cys15 and Cys3-Cys11) <strong>Amount:</strong> 100 ug <strong>Molecular Weight:</strong> 4388.8 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Hoffman A, Grossman E, Keiser HR. Opposite effects of endothelin-1 and Big-endothelin-(1-39) on renal function in rats Eur J Pharmacol. 1990 Jul 17;182(3):603-6. 2: McMahon EG, Palomo MA, Moore WM. Phosphoramidon blocks the pressor activity of big endothelin-38 and lowers blood pressure in spontaneously hypertensive rats J Cardiovasc Pharmacol. 1991;17 Suppl 7:S29-33. 3: Capodicasa E, Tassi C, Rossi R, Biondi R. Plasma endothelin-1 and big endothelin-1 levels in superior and inferior vena cava during protracted antiorthostatic hypokinetic/hypodynamia in rats Clin Chem Lab Med. 2001 Jun;39(6):509-13. 4: Löffler BM, Jacot-Guillarmod H, Maire JP. Concentrations and ratios of immunoreactive big-endothelin-1 and endothelin-1 in human, rat and rabbit plasma Biochem Int. 1992 Aug;27(5):755-61. 5: McMahon EG, Palomo MA, Moore WM, McDonald JF, Stern MK. Phosphoramidon blocks the pressor activity of porcine big endothelin-1-(1-39) in vivo and conversion of big endothelin-1-(1-39) to endothelin-1-(1-21) in vitro Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):703-7. 6: Douglas SA, Robin Hiley C. Responses to endothelin-1, human proendothelin (1-38) and porcine proendothelin (1-39) in the rat on intravenous administration and in the blood perfused mesentery Neurochem Int. 1991;18(4):445-54. 7: Matsumura Y, Ikegawa R, Hisaki K, Tsukahara Y, Takaoka M, Morimoto S. Conversion of big endothelin-1 to endothelin-1 by phosphoramidon-sensitive metalloproteinase derived from aortic endothelial cells J Cardiovasc Pharmacol. 1991;17 Suppl 7:S65-7. 8: Hoffman A, Haramati A, Dalal I, Shuranyi E, Winaver J. Diuretic-natriuretic actions and pressor effects of big-endothelin (1-39) in phosphoramidon-treated rats Proc Soc Exp Biol Med. 1994 Feb;205(2):168-73. 9: Matsumura Y, Hisaki K, Takaoka M, Morimoto S. Phosphoramidon, a metalloproteinase inhibitor, suppresses the hypertensive effect of big endothelin-1 Eur J Pharmacol. 1990 Aug 21;185(1):103-6. <a href="https://pubmed.ncbi.nlm.nih.gov/7476292">10: Zimmerman RS, Maymind M. Endothelin-1 decreases glucose, inhibits glucagon, and stimulates insulin release in the rat Metabolism. 1995 Oct;44(10):1321-5. </a> <br><strong>Products Related to Big Endothelin-1 (Rat, 1-39) can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>