SMARCA2 ligand-12-3-methylazetidine
SMARCA2 ligand-12-3-methylazetidin is a target protein ligand-linker conjugate that incorporates a ligand for SMARCA2 , and a PROTAC linker (HY-W052601), which recruit E3 ligases. SMARCA2 ligand-12-3-methylazetidin can be used to synthesize PROTAC SMARCA2 degrader-25 (HY-169276).
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; Target Protein Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smarca2-ligand-12-3-methylazetidine.html
Smiles
O=C(N1CCN2C3=C(NC[C@H]2C1)N=NC(C4=C(C=CC=C4)O)=C3)C(CC5)CCN5CC6CNC6
Molecular Formula
C25H33N7O2
Molecular Weight
463.58
References & Citations
[1]Liang Lu, et al. Brm targeting compounds and associated methods of use. WO2022099117A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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