PROTAC Her3 Degrader-8
PROTAC Her3 Degrader-8 (Compound PP2) is a Her3 PROTAC degrader. PROTAC Her3 Degrader-8 promotes the ubiquitination and degradation of Her3. PROTAC Her3 Degrader-8 can be used in the study of lung adenocarcinoma and ovarian cancer (Pink: Her3 ligand (HY-107450) ; Blue: E3 ligase ligand (HY-170861) ; Black: linker (HY-Y1760) ) [1].
Product Specifications
CAS Number
[2103331-95-7]
UNSPSC
12352005
Target
EGFR; PROTACs
Type
Reference compound
Related Pathways
JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-her3-degrader-8.html
Purity
99.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=C2C(C(C=C3)=CC(NC(C=C)=O)=C3OC4=CC=CC=C4)=NN(C(CC5)CCN5CC(N[C@H](C(C)(C)C)C(N(C[C@H]6O)[C@H](C6)C(NCC7=CC=C(C(SC=N8)=C8C)C=C7)=O)=O)=O)C2=NC=N1
Molecular Formula
C49H55N11O6S
Molecular Weight
926.10
References & Citations
[1]Bifunctional molescules for her3 degradation and methods of use.WO2017117473.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ErbB3/HER3
Available Sizes
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