D[LEU4, LYS8]-VP (TFA)

D[LEU4, LYS8]-VP TFA is a selective agonist of vasopressin V1b receptor, with the Kis of 0.16 nM, 0.52 nM, and 0.1.38 nM for rat, human and mouse V1b receptor, respectively. D[LEU4, LYS8]-VP TFA has weak antidiuretic, vasopressor, and in vitro oxytocic activities[1][2].

Product Specifications

UNSPSC

12352209

Target

Vasopressin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/d-leu4-lys8-vp-tfa.html

Purity

99.29

Solubility

DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C(F)(F)F.CC(C)C[C@@H]1NC([C@H](CC2=CC=CC=C2)NC([C@H](CC3=CC=C(O)C=C3)NC(CCSSC[C@H](NC([C@H](CC(N)=O)NC1=O)=O)C(N4CCC[C@H]4C(N[C@@H](CCCCN)C(NCC(N)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C49H68F3N11O13S2

Molecular Weight

1140.25

References & Citations

[1]Ana P, et, al. Pharmacological and physiological characterization of d[Leu4, Lys8]vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors. Endocrinology. 2007 Sep; 148 (9) : 4136-46.|[2]Ana P, et, al. Design and synthesis of the first selective agonists for the rat vasopressin V (1b) receptor: based on modifications of deamino-[Cys1]arginine vasopressin at positions 4 and 8. J Med Chem. 2007 Feb 22; 50 (4) : 835-47.