MitTx
MitTx is a complex formed by MitTx-α and MitTx-β. MitTx is an ASIC1 channel activator with EC50 values of 9.4 and 23 nM for ASIC1a and ASIC1b isoforms, respectively. MitTx is highly selective for ASIC1 isoforms at neutral pH. Under acidic conditions, MitTx greatly enhances proton-evoked ASIC2a channel activation[1].
Product Specifications
UNSPSC
12352209
Target
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mittx.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CCCNC(N)=N)C(N1[C@@H](CCC1)C(N[C@@H](C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H]3C(C)C)=O)=O)=O)NC4=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(O)=O)C(N6[C@@H](CCC6)C(N7[C@@H](CCC7)C(N[C@@H](CC8=CC=CC=C8)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC%10=CNC=N%10)C(N[C@@H](CC%11=CC=CC=C%11)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCSC)C(N[C@@H](CO)C(N[C@H]4CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%12=O)C(NCC(N[C@@H](C)C(N[C@@H](CC%13=CC=CC=C%13)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC%14=CC=C(C=C%14)O)C(N[C@@H](CC%15=CC=C(C=C%15)O)C(N[C@@H](CC%16=CC=CC=C%16)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC%17=CNC=N%17)C(NCC(O)=O)=O)=O)NC3=O)C(N[C@@H](C(C)C)C(N[C@@H](CC%18=CNC=N%18)C(N[C@@H](CC%19=CC=CC=C%19)C(N[C@@H](CC%20=CC=CC=C%20)C(N[C@@H](CC%21=CC=C(C=C%21)O)C(NCC(N[C@H]%12CCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)NC([C@@H]%22CCC(N%22)=O)=O.O=C([C@@H](N)CC(N)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N%23[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]%24CSSC[C@H](NC%25=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N%26[C@H](C(N[C@H](C(N[C@H]%27CCCNC(N)=N)=O)CO)=O)CCC%26)=O)CC(O)=O)=O)[C@H](CC)C)=O)CCCCN)=O)CC%28=CNC=N%28)=O)CC(N)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CC%29=CC=C(O)C=C%29)=O)[C@@H](C)O)=O)C)=O)[C@@H](C)O)=O)CC(C)C)=O)[C@H](CC)C)=O)=O)CCCNC(N)=N)=O)CC(O)=O)=O)CC(C)C)=O)CC(O)=O)=O)CC(O)=O)=O)C(C)C)=O)CCC%23)=O)[C@@H](C)O)=O)CC(N)=O)=O)CO)=O)CC(O)=O)=O)CCCNC(N)=N)=O)C)=O)C(C)C)=O)CSSC[C@H](NC%24=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NC(C(NC(C(N%30C(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC%31CCC(O)=O)=O)CC%32=CC=CC=C%32)=O)CO)=O)CC%33=CC=C(O)C=C%33)=O)CC%34=CC=CC=C%34)=O)CCSC)=O)C(C)C)=O)CC(C)C)=O)CCC%30)=O)CCCCN)=O)CSSC[C@H](NC%35=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]%36C(C)C)=O)CC%37=CC=CC=C%37)=O)CC(N)=O)=O)CCCNC(N)=N)=O)=O)=O)CC%38=CNC=N%38)=O)C(C)C)=O)CCCCN)=O)C(C)C)=O)C)=O)CCC(O)=O)=O)CC(O)=O)=O)CC%39=CC=C(O)C=C%39)=O)CSSC[C@H](NC%40=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]%25CC(C)C)=O)[C@@H](C)O)=O)C)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)CC(O)=O)=O)=O)CCC(N)=O)=O)CCCCN)=O)CCC(N)=O)=O)C)=O)CCC(N)=O)=O)=O)CC%41=CC=C(O)C=C%41)=O)CSSC[C@H](NC%27=O)C(N[C@H](C(O)=O)CCC(N)=O)=O)=O)=O)CC%42=CC=C(O)C=C%42)=O)CC(O)=O)=O)C(C)C)=O)CC%43=CC=CC=C%43)=O)CC(O)=O)=O)C)=O)CC%44=CNC%45=CC=CC=C%44%45)=O)C(C)C)=O)CCCNC(N)=N)=O)CC(O)=O)=O)CC(N)=O)=O)[C@@H](C)O)=O)CSSCC(NC%31=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]%35CCCCN)=O)[C@@H](C)O)=O)CC(N)=O)=O)CC(N)=O)=O)=O)CO)=O)CSSC[C@H](NC%36=O)C(N[C@H]%40CC(N)=O)=O)=O)CC(O)=O)=O)CC(C)C)=O)CC(O)=O)=O)CO)=O)C)=O)CC(C)C)=O)CC%46=CC=C(O)C=C%46)=O)CCCNC(N)=N)=O)=O)CCCCN)=O)[C@H](CC)C)=O)CCSC)=O)CC(C)C)=O)CCCNC(N)=N)=O)CC%47=CC=CC=C%47)=O)CCC(N)=O)=O)CC(N)=O)=O)CC(C)C
Molecular Formula
C899H1331N259O271S23
Molecular Weight
20840.26
References & Citations
[1]Bohlen CJ, et al. A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature. 2011 Nov 16;479 (7373) :410-4.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
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