XM-U-14

XM-U-14 is a selective PROTAC USP7 Degrader (DC50: 0.74 nM in inducing USP7 degradation in RS4;11 cell line) . XM-U-14 upregulates the levels of p53 and p21. XM-U-14 also significantly inhibits acute lymphoblastic leukemia (ALL) cell growth (IC50: 0.5 nM and 8.3 nM for RS4;11 cells and Reh cells respectively) . XM-U-14 induces apoptosis and cycle arrest. XM-U-14 inhibits tumor growth. (Blue: VHL ligand (HY-159465), Black: linker (HY-W539783) ; Pink: USP7 inhibitor (HY-159464) ) [1].

Product Specifications

CAS Number

[3098519-83-3]

UNSPSC

12352005

Target

Apoptosis; Deubiquitinase; MDM-2/p53; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xm-u-14.html

Smiles

CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)C)C4=CC(N5CCN(CC5)CC6=CC=C(C=C6)C7=C(C8=NN7C)N=CN(C8=O)CC9(CCN(CC9)C(C[C@@H](C)C%10=CC=CC=C%10)=O)O)=NO4)=O)=O

Molecular Formula

C58H69N11O7S

Molecular Weight

1064.30

References & Citations

[1]Xu M, et al. Discovery of a Highly Potent, Selective and Efficacious USP7 Degrader for the Treatment of Acute Lymphoblastic Leukemia. J Med Chem. 2024 Jul 19.