XM-U-14
Product Specifications
UNSPSC Description
XM-U-14 is a selective PROTAC USP7 Degrader (DC50: 0.74 nM in inducing USP7 degradation in RS4;11 cell line). XM-U-14 upregulates the levels of p53 and p21. XM-U-14 also significantly inhibits acute lymphoblastic leukemia (ALL) cell growth (IC50: 0.5 nM and 8.3 nM for RS4;11 cells and Reh cells respectively). XM-U-14 induces apoptosis and cycle arrest. XM-U-14 inhibits tumor growth. (Blue: VHL ligand (HY-159465), Black: linker (HY-W539783); Pink: USP7 inhibitor (HY-159464))[1].
Target Antigen
Apoptosis; Deubiquitinase; MDM-2/p53; PROTACs
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xm-u-14.html
Smiles
CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)C)C4=CC(N5CCN(CC5)CC6=CC=C(C=C6)C7=C(C8=NN7C)N=CN(C8=O)CC9(CCN(CC9)C(C[C@@H](C)C%10=CC=CC=C%10)=O)O)=NO4)=O)=O
Molecular Weight
1064.30
References & Citations
[1]Xu M, et al. Discovery of a Highly Potent, Selective and Efficacious USP7 Degrader for the Treatment of Acute Lymphoblastic Leukemia. J Med Chem. 2024 Jul 19.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159175/XM-U-14-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159175/
Clinical Information
No Development Reported
Curated Selection
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