XM-U-14
XM-U-14 is a selective PROTAC USP7 Degrader (DC50: 0.74 nM in inducing USP7 degradation in RS4;11 cell line). XM-U-14 upregulates the levels of p53 and p21. XM-U-14 also significantly inhibits acute lymphoblastic leukemia (ALL) cell growth (IC50: 0.5 nM and 8.3 nM for RS4;11 cells and Reh cells respectively). XM-U-14 induces apoptosis and cycle arrest. XM-U-14 inhibits tumor growth. (Blue: VHL ligand , Black: linker (HY-W539783) ; Pink: USP7 inhibitor (HY-159464) ).
Product Specifications
CAS Number
3098519-83-3
UNSPSC
12352005
Target
Apoptosis; Deubiquitinase; MDM-2/p53; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xm-u-14.html
Smiles
Molecular Formula
C58H69N11O7S
Molecular Weight
1064.30
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
USP7
Frequently Asked Questions
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