PROTAC BRD4 Degrader-26
PROTAC BRD4 Degrader-26 (PROTAC-2) is a photo-regulated PROTAC, which degrades 80% BRD4 at 1 μM by using photocleavable linker. PROTAC BRD4 Degrader-26 will be deactivated by UV light. (Pink: ligand for target protein BRD4 ligand 6 ; Black: linker (HY-161653) ; Blue: E3 ligase ligand Thalidomide 4-fluoride (HY-41547) )
Product Specifications
CAS Number
3050769-37-1
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-brd4-degrader-26.html
Smiles
O=C(C1=C(NCCCOC2=CC(COC(NCCCNC(C[C@H]3C4=NN=C(C)N4C(SC(C)=C5C)=C5C(C6=CC=C(Cl)C=C6)=N3)=O)=O)=C([N+]([O-])=O)C=C2)C=CC=C17)N(C8C(NC(CC8)=O)=O)C7=O
Molecular Formula
C46H45ClN10O10S
Molecular Weight
965.43
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Frequently Asked Questions
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