Gossypetin
Gossypetin is a hexahydroxylated flavonoid and is a potent mitogen-activated protein kinase kinase (MKK) 3 and MKK6 inhibitor with strongly attenuates the MKK3/6-p38 signaling pathway, has various pharmacological activities, including antioxidant, antibacterial and anticancer activities[1].
Product Specifications
CAS Number
[489-35-0]
UNSPSC
12352005
Target
Bacterial; MEK; p38 MAPK
Type
Natural Products
Related Pathways
Anti-infection; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/gossypetin.html
Purity
99.82
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C(O)=C(OC2=C1C(O)=CC(O)=C2O)C3=CC(O)=C(C=C3)O
Molecular Formula
C15H10O8
Molecular Weight
318.24
References & Citations
[1]Xie X, et al. Gossypetin is a novel MKK3 and MKK6 inhibitor that suppresses esophageal cancer growth in vitro and in vivo. Cancer Lett. 2019 Feb 1;442:126-136.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
P38 MAPK
Available Sizes
Curated Selection
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