IMPDH2-IN-2
Product Specifications
UNSPSC Description
IMPDH2-IN-2 is a potent inhibitor of inosine 5’-monophosphate dehydrogenase (IMPDH) with a Ki,app value of 14 μM, respectively. IMPDH2-IN-2 displays moderate antibacterial activity (MIC = 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively). IMPDH2-IN-2 is a potential anti-tuberculosis agent[1].
Target Antigen
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/impdh2-in-2.html
Solubility
DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
C[C@H](OC1=CC=CC(Cl)=C1Cl)C(NC2=CC=C(OC(C3=CC=NC=C3)=N4)C4=C2)=O
Molecular Weight
428.27
References & Citations
[1]Chacko S, et al. Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents [published correction appears in J Med Chem. 2021 Dec 23;64(24):18233-18234]. J Med Chem. 2018;61(11):4739-4756.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145286/IMPDH2-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145286/IMPDH2-IN-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1434517-02-8
Available Sizes
Curated Selection
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