IMPDH2-IN-2

IMPDH2-IN-2 is a potent inhibitor of inosine 5’-monophosphate dehydrogenase (IMPDH) with a Ki, app value of 14 μM, respectively. IMPDH2-IN-2 displays moderate antibacterial activity (MIC = 6.3 and 11 μM in minimal GAST/Fe and rich 7H9/ADC/Tween media, respectively) . IMPDH2-IN-2 is a potential anti-tuberculosis agent[1].

Product Specifications

CAS Number

[1434517-02-8]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/impdh2-in-2.html

Purity

99.73

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@H](OC1=CC=CC(Cl)=C1Cl)C(NC2=CC=C(OC(C3=CC=NC=C3)=N4)C4=C2)=O

Molecular Formula

C21H15Cl2N3O3

Molecular Weight

428.27

References & Citations

[1]Chacko S, et al. Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents [published correction appears in J Med Chem. 2021 Dec 23;64 (24) :18233-18234]. J Med Chem. 2018;61 (11) :4739-4756.