α-Cyclodextrin

α-Cyclodextrin (α-CD) is a soluble fiber derived from corn. α-Cyclodextrin can deplete sphingolipids and phospholipids from cell membranes. α-Cyclodextrin interacts with tubulin. α-Cyclodextrin improves defenses against SARS-CoV-2 infection. α-Cyclodextrin enhances the anticancer efficacy of Crcumin (HY-N0005) against breast, lung and cervical cancer. α-Cyclodextrin has beneficial effects on body weight and blood lipids[1][2][3][4][5].

Product Specifications

CAS Number

[10016-20-3]

UNSPSC

12352005

Hazard Statement

H319

Target

Microtubule/Tubulin; SARS-CoV

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer; Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/_alpha_-Cyclodextrin.html

Purity

99.83

Solubility

DMSO : 110 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

OC[C@@H](O[C@@](O[C@]([C@@H]1O)([H])[C@H](O[C@@](O[C@]([C@@H]2O)([H])[C@H](O[C@@](O[C@@]3([H])[C@@H]4O)([H])[C@@H]2O)CO)([H])[C@@H]1O)CO)([H])[C@@H]5O)[C@](O[C@](O[C@H](CO)[C@](O[C@](O[C@H](CO)[C@](O[C@](O[C@@H]3CO)([H])[C@@H]4O)([H])[C@@H]6O)([H])[C@@H]6O)([H])[C@@H]7O)([H])[C@@H]7O)([H])[C@@H]5O

Molecular Formula

C36H60O30

Molecular Weight

972.84

Precautions

H319

References & Citations

[1]Comerford KB, et al. The beneficial effects of α-cyclodextrin on blood lipids and weight loss in healthy humans. Obesity (Silver Spring) . 2011 Jun;19 (6) :1200-4.|[2]Paolacci S, et al. In vitro and clinical studies on the efficacy of α-cyclodextrin and hydroxytyrosol against SARS-CoV-2 infection. Eur Rev Med Pharmacol Sci. 2021 Dec;25 (1 Suppl) :81-89.|[3]Jana B, et al. α-Cyclodextrin Interacts Close to Vinblastine Site of Tubulin and Delivers Curcumin Preferentially to the Tubulin Surface of Cancer Cell. ACS Appl Mater Interfaces. 2016 Jun 8;8 (22) :13793-803.|[4]Lina BA, et al. Subchronic oral toxicity studies with alpha-cyclodextrin in rats. Regul Toxicol Pharmacol. 2004 Jun;39 Suppl 1:S14-26.|[5]Lina BA, et al. Subchronic (13-week) oral toxicity study of alpha-cyclodextrin in dogs. Regul Toxicol Pharmacol. 2004 Jun;39 Suppl 1:S27-33.