[Au(L4)(CyJohnPhos)]SbF6
Product Specifications
UNSPSC Description
[Au(L4)(CyJohnPhos)]SbF6 is a gold containing complex. [Au(L4)(CyJohnPhos)]SbF6 inhibits cyclooxygenase-1/2 (COX-1/2), inhibits the proliferation (IC50 is 0.98 μM) and induces apoptosis in colon cancer cell Caco2-/TC7. [Au(L4)(CyJohnPhos)]SbF6 is also an inhibitor for thioredoxin reductase (TrxR), thereby exhibits antioxidant activity by modulating ROS levels[1].
Target Antigen
Apoptosis; COX; Reactive Oxygen Species; TrxR
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Field of Research
Cancer; Inflammation/Immunology
Smiles
COC1=CC2=C(C=C1)C=C([C@H](C)C(NC(CC[S]([Au+][P](C3CCCCC3)(C4CCCCC4)C5=CC=CC=C5C6=CC=CC=C6)C)C(OC)=O)=O)C=C2.F[Sb](F)(F)(F)F.[F-]
Molecular Weight
1158.68
References & Citations
[1]Saez J, et al., Gold(I) Complexes Based on Nonsteroidal Anti-Inflammatory Derivatives as Multi-Target Drugs against Colon Cancer. Inorg Chem. 2024 Oct 21;63(42):19769-19782.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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