GM-90257
GM-90257 is a microtubule acetylation inhibitor. GM-90257 binds directly to α-tubulin. GM-90257 prevents the recruitment of α-tubulin acetyltransferase 1 (αTAT1) to the K40 residue in α-tubulin. GM-90257 causes Apoptosis, downregulates BCl-2, and activates JNK and PARP. GM-90257 has anticancer activity against breast cancer[1][2].
Product Specifications
CAS Number
315703-81-2
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; JNK; Microtubule/Tubulin; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; MAPK/ERK Pathway
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gm-90257.html
Purity
99.90
Smiles
CC(N=C1SC=CN12)=C2C3=CSC(NC4=CC=C(C=C4)OC)=N3
Molecular Formula
C16H14N4OS2
Molecular Weight
342.44
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2
Available Sizes
Frequently Asked Questions
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