GM-90257

GM-90257 is a microtubule acetylation inhibitor. GM-90257 binds directly to α-tubulin. GM-90257 prevents the recruitment of α-tubulin acetyltransferase 1 (αTAT1) to the K40 residue in α-tubulin. GM-90257 causes Apoptosis, downregulates BCl-2, and activates JNK and PARP. GM-90257 has anticancer activity against breast cancer[1][2].

Product Specifications

CAS Number

[315703-81-2]

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; JNK; Microtubule/Tubulin; PARP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; MAPK/ERK Pathway

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gm-90257.html

Purity

99.90

Smiles

CC(N=C1SC=CN12)=C2C3=CSC(NC4=CC=C(C=C4)OC)=N3

Molecular Formula

C16H14N4OS2

Molecular Weight

342.44

References & Citations

[1]Ahreum Kwon, et al. Potent Small-Molecule Inhibitors Targeting Acetylated Microtubules as Anticancer Agents Against Triple-Negative Breast Cancer. Biomedicines. 2020 Sep 9;8 (9) :338. |[2]Ahn S, et al. Microtubule Acetylation-Specific Inhibitors Induce Cell Death and Mitotic Arrest via JNK/AP-1 Activation in Triple-Negative Breast Cancer Cells. Mol Cells. 2023 Jun 30;46 (6) :387-398.