Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate[1].
Product Specifications
CAS Number
[1599440-20-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gly-gly-phe-gly-nh-ch2-o-ch2cooh.html
Purity
99.98
Solubility
DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 100 mg/mL (ultrasonic) |DMSO : 3 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
OC(COCNC(CNC([C@@H](NC(CNC(CN)=O)=O)CC1=CC=CC=C1)=O)=O)=O
Molecular Formula
C18H25N5O7
Molecular Weight
423.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Masuda, et al. Preparation of antibody-drug conjugates for cancer therapy. World Intellectual Property Organization, WO2014057687 A1. 2014-04-17.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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