AGRP rabbit pAb

Disease: Defects in AGRP may be a cause of autosomal dominant obesity [MIM: 601665]. Domain: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. function: Plays a role in weight homeostasis. May play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding. similarity: Contains 1 agouti domain. tissue specificity: Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.