FXR agonist 11
FXR agonist 11 (Compound 14) is an FXR agonist with an EC50 of 1.2 μM and a maximum effect of 73.7%. FXR agonist 11 can significantly increase GSH levels in the liver and is used to study drug-induced liver injury diseases[1].
Product Specifications
CAS Number
2768502-17-4
UNSPSC
12352005
Target
FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fxr-agonist-11.html
Smiles
OC(C1=CC=CC(NC(COC2=CC=C3C(NC(CC3)=O)=C2)=O)=C1)=O
Molecular Formula
C18H16N2O5
Molecular Weight
340.33
References & Citations
[1]Qianqian Qiu, et al. Design, synthesis, and biological evaluation of novel FXR agonists based on auraptene. Bioorg Chem. 2021 Oct:115:105198.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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