E2508
E2508 is an orally active corticotropin-releasing factor 1 (CRF1) receptor antagonist with a Ki value of 11 nM for hCRF1[1].
Product Specifications
CAS Number
685886-34-4
UNSPSC
12352005
Target
CRFR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/e2508.html
Smiles
CCC1=NN2C(C3=C(OC)C=C(COC)C=C3OC)=CC=CC2=C1N(CC4CC4)CC5CCOCC5.O=S(C6=CC=C(C)C=C6)(O)=O
Molecular Formula
C36H47N3O7S
Molecular Weight
665.84
References & Citations
[1]Takahashi Y, et al. Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem. 2012 Jun 14;55 (11) :5255-69.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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