PD-L1-IN-6
PD-L1-IN-6 (Compound 16) is an orally active inhibitor for PD-L1 expression in neutrophil by targeting STAT3 with KD of 90.5 nmol/L. PD-L1-IN-6 promotes neutrophil-mediated antifungal immunoresponse[1].
Product Specifications
UNSPSC
12352005
Target
PD-1/PD-L1; STAT
Type
Reference compound
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pd-l1-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C1O[C@@H]2[C@@]3([C@@]4([C@](C)(CC[C@H]2[C@@H]1CS(=O)(C5=C(C=CC=C5Cl)Cl)=O)O4)CC[C@]3(O)C)[H]
Molecular Formula
C21H24Cl2O6S
Molecular Weight
475.38
References & Citations
[1]Lu X, et al., Drug Repurposing of ACT001 to Discover Novel Promising Sulfide Prodrugs with Improved Safety and Potent Activity for Neutrophil-Mediated Antifungal Immunotherapy. J Med Chem. 2024 Mar 25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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