Anti-Hu CD156c PE
CD156c is a type I transmembrane glycoprotein with a zinc-dependent metalloprotease activity. It serves as an endopeptidase of broad specificity, which is expressed mainly in thymus, liver, and muscles. Its expression can be induced in inflamed central nervous system, and in arthritic tissues. CD156c is involved in multiple sclerosis-associated myelin degradation. It also solubilizes various membrane proteins, including CD23, CD44, CD126, CD171, ephrin-A2, and other.
Product Specifications
Certification
RUO
Negative Species
Mouse
Reactivity
Human
Immunogen
Jurkat cells
Target Antigen
CD156c
Clone
11G2
Applications
FC (QC tested)
Format
PE
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Zola H et al.: Leukocyte and Stromal Cell Molecules, Wiley 2007, URL: , *Arduise C, Abache T, Li L, Billard M, Chabanon A, Ludwig A, Mauduit P, Boucheix C, Rubinstein E, Le Naour F: Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor. J Immunol. 2008 Nov 15;181 (10) :7002-13., URL: https://pubmed.ncbi.nlm.nih.gov/18981120/, *Saint-Pol J, Billard M, Dornier E, Eschenbrenner E, Danglot L, Boucheix C, Charrin S, Rubinstein E: New insights into the tetraspanin Tspan5 using novel monoclonal antibodies. J Biol Chem. 2017 Jun 9;292 (23) :9551-9566., URL: https://pubmed.ncbi.nlm.nih.gov/28428248/
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The mouse monoclonal antibody 11G2 recognizes an extracellular/luminal epitope of CD156c, a type I transmembrane glycoprotein, serving as a zinc-dependent metalloprotease.
Applications Notes
6
Isotype
Mouse IgG1 kappa
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