Flavagline FL3
Flavagline FL3 is a flavagline with potent and selective cytotoxicity in cancer cells.Flavagline FL3 induces apoptosis of HL60 and Hela cells by triggering the translocation of Apoptosis Inducing Factor (AIF) and caspase-12 to the nucleus[1].
Product Specifications
CAS Number
1186012-80-5
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flavagline-fl3.html
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@@H]1C[C@H]([C@@]2(OC3=CC(OC)=CC(OC)=C3[C@@]21O)C4=CC=C(C=C4)Br)C5=CC=CC=C5
Molecular Formula
C25H23BrO5
Molecular Weight
483.35
References & Citations
[1]Frédéric Thuaud, et al. Synthetic analogue of rocaglaol displays a potent and selective cytotoxicity in cancer cells: involvement of apoptosis inducing factor and caspase-12. J Med Chem. 2009 Aug 27;52 (16) :5176-87.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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