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Flavagline FL3

Flavagline FL3 is a flavagline with potent and selective cytotoxicity in cancer cells.Flavagline FL3 induces apoptosis of HL60 and Hela cells by triggering the translocation of Apoptosis Inducing Factor (AIF) and caspase-12 to the nucleus[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/flavagline-fl3.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@@H]1C[C@H]([C@@]2(OC3=CC(OC)=CC(OC)=C3[C@@]21O)C4=CC=C(C=C4)Br)C5=CC=CC=C5

Molecular Formula

C25H23BrO5

Molecular Weight

483.35

References & Citations

[1]Frédéric Thuaud, et al. Synthetic analogue of rocaglaol displays a potent and selective cytotoxicity in cancer cells: involvement of apoptosis inducing factor and caspase-12. J Med Chem. 2009 Aug 27;52 (16) :5176-87.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-123554/Flavagline-FL3-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-123554/Flavagline-FL3-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

CAS Number

[1186012-80-5]

Available Sizes

Curated Selection

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