Flavagline FL3

Flavagline FL3 is a flavagline with potent and selective cytotoxicity in cancer cells.Flavagline FL3 induces apoptosis of HL60 and Hela cells by triggering the translocation of Apoptosis Inducing Factor (AIF) and caspase-12 to the nucleus[1].

Product Specifications

CAS Number

[1186012-80-5]

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/flavagline-fl3.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@@H]1C[C@H]([C@@]2(OC3=CC(OC)=CC(OC)=C3[C@@]21O)C4=CC=C(C=C4)Br)C5=CC=CC=C5

Molecular Formula

C25H23BrO5

Molecular Weight

483.35

References & Citations

[1]Frédéric Thuaud, et al. Synthetic analogue of rocaglaol displays a potent and selective cytotoxicity in cancer cells: involvement of apoptosis inducing factor and caspase-12. J Med Chem. 2009 Aug 27;52 (16) :5176-87.