PDK1-IN-RS2

PDK1-IN-RS2 is a mimic of peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor with a Kd of 9 μM. PDK1-IN-RS2 suppresses the activation of the downstream kinases S6K1 by PDK1[1].

Product Specifications

CAS Number

[1643958-89-7]

Product Name Alternative

Xanthothricin; Toxoflavine; PKF-118-310

UNSPSC

12352005

Target

PDK-1

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pdk1-in-rs2.html

Purity

98.49

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=S(C1=CC2=CC=CC=C2S1)(NC3=NC4=CC=C(C=C4S3)Cl)=O

Molecular Formula

C15H9ClN2O2S3

Molecular Weight

380.89

References & Citations

[1]Rettenmaier TJ, et al. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proc Natl Acad Sci U S A. 2014 Dec 30;111 (52) :18590-5.