(2S,4S) -Sacubitril-d4

(2S,4S) -Sacubitril-d4 is deuterium labeled (2S,4S) -Sacubitril. (2S,4S) -Sacubitril is the impurity of Sacubitril. Sacubitril is a potent NEP inhibitor that can be used for the research of heart failure[1][2].

Product Specifications

UNSPSC

12352005

Target

Drug Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Cardiovascular Disease

Smiles

CCOC([C@@H](C)C[C@H](NC(C([2H])([2H])C([2H])([2H])C(O)=O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1)=O

Molecular Formula

C24H25D4NO5

Molecular Weight

415.52

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Shi J, et al. Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation. Drug Metab Dispos. 2016 Apr;44 (4) :554-9.|[3]Halama A, et, al. Synthesis, Isolation, and Analysis of Stereoisomers of Sacubitril. Org. Process Res. Dev. 2019, 23, 1, 102-107.