Levamisole
Product Specifications
UNSPSC Description
Levamisole ((-)-Levamisole), an anthelmintic agent with immunomodulatory properties. Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC50=300 μM) and α3β4 (EC50=100 μM) subtype of nAChRs. Orally active[1][2].
Target Antigen
nAChR; Parasite
Type
Reference compound
Related Pathways
Anti-infection;Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/s-minus-levamisole.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C12=N[C@@H](C3=CC=CC=C3)CN1CCS2
Molecular Weight
204.298
References & Citations
[1]Lewis JA, et al. Levamisole: A Positive Allosteric Modulator for the α3β4 Nicotinic Acetylcholine Receptors Prevents Weight Gain in the CD-1 Mice on a High Fat Diet. Curr Pharm Des. 2017;23(12):1869-1872. |[2]Mehta KP, et al. Immunoregulatory treatment for minimal change nephrotic syndrome. Arch Dis Child. 1986;61(2):153-158. Rapid Commun Mass Spectrom. 2022 Nov 16;e9430.|bioRxiv. 2023 Oct 15.|Environ Sci Pollut Res Int. 2022 Sep 16.|J Ethnopharmacol. 2024 Jun 3:118406.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-A0106/Levamisole-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-A0106/Levamisole-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
14769-73-4
Available Sizes
Curated Selection
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