Levamisole

Levamisole ((-) -Levamisole), an anthelmintic agent with immunomodulatory properties. Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC50=300 μM) and α3β4 (EC50=100 μM) subtype of nAChRs. Orally active[1][2].

Product Specifications

CAS Number

[14769-73-4]

Product Name Alternative

(-) -Tetramisole

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NAChR; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/s-minus-levamisole.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C12=N[C@@H](C3=CC=CC=C3)CN1CCS2

Molecular Formula

C11H12N2S

Molecular Weight

204.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Lewis JA, et al. Levamisole: A Positive Allosteric Modulator for the α3β4 Nicotinic Acetylcholine Receptors Prevents Weight Gain in the CD-1 Mice on a High Fat Diet. Curr Pharm Des. 2017;23 (12) :1869-1872. |[2]Mehta KP, et al. Immunoregulatory treatment for minimal change nephrotic syndrome. Arch Dis Child. 1986;61 (2) :153-158.