L-750667 (triHydrochloride)

L-750667 triHydrochloride is a selective antagonist for the D4 dopamine receptor, with a Ki value of 0.51 nM. The radiolabeled form of L-750667, [125I]L-750,667, has a Kd value of 0.16 nM for the D4 receptor. L-750667 triHydrochloride can reverse dopamine-induced inhibition of cAMP accumulation. It can be used to study the distribution and function of D4 dopamine receptors in the central nervous system and has potential applications in the fields of neuroscience and psychiatry[1][2].

Product Specifications

CAS Number

[1021868-80-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-750667-trihydrochloride.html

Purity

99.39

Solubility

DMSO : 8.33 mg/mL (ultrasonic)

Smiles

IC1=CC=C(C=C1)N2CCN(CC2)CC3=CNC4=NC=CC=C43.[H]Cl.[H]Cl.[H]Cl

Molecular Formula

C18H22Cl3IN4

Molecular Weight

527.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Staley JK, et al. SPECT imaging with the D (4) receptor antagonist L-750,667 in nonhuman primate brain. Nucl Med Biol. 2000 Aug;27 (6) :547-56.|[2]Patel S, et al. Identification and pharmacological characterization of [125I]L-750,667, a novel radioligand for the dopamine D4 receptor. Mol Pharmacol. 1996 Dec;50 (6) :1658-64.