L-751788
L-751788 is a selective inhibitor of type I of 5α-reductase. L-751788 does not have a significant impact on the differentiation of the external genitalia in animals. When administered orally to pregnant rhesus monkeys, L-751788 (2, 10 mg/kg) did not cause abnormalities in fetal external genitalia[1].
Product Specifications
CAS Number
166174-54-5
UNSPSC
12352005
Target
5 alpha Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/l-751788.html
Smiles
O=C1N([C@@]2(C[C@@H]([C@@]3([H])[C@@]4(C[C@@H](C[C@]4(CC[C@@]3([C@]2(CC1)C)[H])C)OC5=CC=C(C=C5)Cl)[H])C)[H])C
Molecular Formula
C26H36ClNO2
Molecular Weight
430.02
References & Citations
[1]Voegeli R, et al. 5a-Reductase and Its Inhibitors[M]//Acne and Its Therapy. CRC Press, 2007: 181-216.|[2]Prahalada S, et al. Effects of finasteride, a type 2 5‐alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta) [J]. Teratology, 1997, 55 (2) : 119-131.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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