SGK1-IN-3 (hydrochloride)
SGK1-IN-3 hydrochloride (compound 3a) is a potent SGK1 inhibitor with an IC50 of [1].
Product Specifications
UNSPSC
12352005
Target
SGK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sgk1-in-3-hydrochloride.html
Purity
96.65
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C2=CC=C(C=C2)NS(=O)(C3=C(C(Cl)=CC=C3)Cl)=O)=NC4=C1C=NN4)N[C@@H]5CCNC5.[H]Cl
Molecular Formula
C23H21Cl3N6O3S
Molecular Weight
567.88
References & Citations
[1]Halland N, et al. Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis. J Med Chem. 2022;65 (2) :1567-1584.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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