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Quinidine hydrochloride monohydrate

Quinidine hydrochloride monohydrate is an anti-arrythmic agent which is also a potent blocker of K+ channel with an IC50 of 19.9 μM[1][2].

Product Specifications

CAS Number

[6151-40-2]

UNSPSC

12352005

Hazard Statement

H302, H316, H317, H335

Target

Parasite; Potassium Channel

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Quinidine_hydrochloride_monohydrate.html

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 2.5 mg/mL (ultrasonic)

Smiles

C=C[C@H]1C[N@](CC[C@H]1C2)[C@@]2([H])[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34.[H]Cl.[H]O[H]

Molecular Formula

C20H27ClN2O3

Molecular Weight

378.89

Precautions

H302, H316, H317, H335

References & Citations

[1]Wrighton DC, et al. Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium. Br J Pharmacol. 2015 Sep;172 (17) :4355-63.|[2]Cheng KI, et al. Application of quinidine on rat sciatic nerve decreases the amplitude and increases the latency of evoked responses. J Anesth. 2014 Aug;28 (4) :559-68.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Plasmodium

Citation 01

Cell Mol Life Sci. 2025 Nov 25;82 (1) :419.|Pharmaceutics. 2025 Mar 26;17 (4) :423.|AAPS J. 2021 Jun 28;23 (4) :91.|Adv Sci (Weinh) . 2025 Aug 19:e05666.|Anal Chem. 2025 Nov 18;97 (45) :25158-25167.|Andrology. 2024 Nov 05.|Chemosphere. 2021 Dec:284:131347.|Environ Int. 2019 Jun;127:694-703. |Environ Pollut. 2024 May 25:124214.|Eur J Drug Metab Pharmacokinet. 2022 Sep;47 (5) :639-652.|Food Chem Toxicol. 2022 Nov:169:113431.|Front Pharmacol. 2020 Jul 31;11:1038.|J Agric Food Chem. 2022 Mar 2;70 (8) :2520-2528.|J Anim Sci. 2022 Apr 1;100 (4) :skac069.|J Hazard Mater. 2021 Aug 15:416:125764.|J Med Chem. 2020 Oct 8;63 (19) :11085-11099.|J Med Chem. 2021 Mar 11;64 (5) :2725-2738.|Pharmacol Res Perspect. 2020 Apr;8 (2) :e00575.|Pharmacol Res Perspect. 2021 Oct;9 (5) :e00879.|RSC Adv. 2019 May 23;9 (28) :16136-16146.|Virol J. 2024 Aug 8;21 (1) :181.|Nat Commun. 2024 Jun 19;15 (1) :5230.

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